Bulletproof Radio

Can Happiness Really Be Engineered? Mo Gawdat Says Yes—And Here’s How.  I know what you’re thinking… ANOTHER episode on happiness? Haven’t we heard it all before? This one’s different. The code is cracked, and you’re about to learn exactly how it works. Joining us today is Mo Gawdat, bestselling author of Unstressable and former Chief Business Officer of Google X. Mo sits down with Dave to deliver a practical, science-backed approach to hacking your mind and body for lasting joy. Mo dives into the raw science behind happiness and stress—revealing how your brain runs on algorithms that you can actually reprogram. Discover why dopamine might be sabotaging your joy, how to decode the four types of stress, and biohacks that can flip the script on your mental and physical resilience. He also shares the deeply personal story of how he turned unimaginable tragedy into a global mission for happiness and purpose. Mo’s insights will challenge everything you thought you knew about living a fulfi

Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit?  Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit and honey alongside animal-based nutrition, and why metabolic flexibility—not rigid rules—leads to better outcomes. Together, he and Dave challenge assumptions about long-term ketosis, examine its potential downsides, and explore how to optimize diets for energy, gut health, and longevity. They also tackle controversial topics like the risks of seed oils, the overhyped reputation of “health foods” like quinoa, and the critical roles insulin and nutrient density play in overall wellness. With insights on balancing mTOR, managing omega fats, and incorporating organ meats, this episode offers a nuanced perspective f

What are the oral hygiene tips that could save your life?  Dave Asprey sits down with one of the most popular guests on the show, Naveen Jain, founder and CEO of Viome Life Sciences, to explore how your oral microbiome influences not just your dental health but your entire body. Naveen reveals groundbreaking insights into how imbalances in oral bacteria can trigger chronic inflammation, heart disease, and even cancer—and how understanding your unique microbiome can help prevent these risks. Discover why oral health goes far beyond brushing and flossing, how to optimize your oral microbiome for longevity, and why common mouthwashes may be doing more harm than good. Naveen also introduces cutting-edge solutions from Viome, including personalized oral lozenges and postbiotics, to elevate both your oral and overall health. In this episode, you’ll also uncover the exact foods to eat and avoid to live a longer, healthier, and more vibrant life. What you’ll learn in this episode:  • The surp

Is this the missing link in fertility? The vaginal microbiome could be the most overlooked factor in optimizing women’s health, from fertility and hormonal balance to preventing infections and improving quality of life. In this groundbreaking episode, Dave Asprey talks to Priyanka Jain, co-founder and CEO of Evvy, about how understanding and improving the vaginal microbiome can transform women’s health outcomes. Priyanka shares how Evvy is advancing women’s health through cutting-edge genomic research and AI-powered insights, offering solutions to challenges like bacterial vaginosis, yeast infections, recurrent UTIs, and even infertility. You’ll learn why this critical microbiome plays such a vital role, how hormonal changes and lifestyle impact it, and how personalized approaches can improve reproductive and overall health. This episode explores not just women’s health but also how understanding the vaginal microbiome can influence relationships, biohacking, and even groundbreaking fertility r

Is alcohol losing its grip as the go-to social drink? Enter kava—a centuries-old Polynesian plant that’s gaining global recognition for its ability to relax the mind, elevate mood, and enhance social connection without the toxic effects of alcohol. Kava, particularly in the form of TRU KAVA, is a psychoactive yet non-intoxicating drink that offers the perfect balance of calm focus and mental clarity. In this episode, Dave Asprey welcomes Cameron George, founder of TRU KAVA, to discuss why kava is becoming the drink of choice for those seeking a healthier, more connected lifestyle. Learn how kava impacts neurotransmitters like GABA and dopamine, enhances creativity and emotional grounding, and even helps the body recover from stress and trauma. Discover why kava is taking center stage in the biohacking and sober-curious movements as a new tool for wellness and connection. Here’s what you’ll learn in this episode:  • Why 41% of Americans and 61% of Gen Z are drinking less alcohol  • Wha

Have we finally discovered the key to youthful energy, longevity, and cellular health? In this episode, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer at Timeline Nutrition and a leading expert on mitochondrial health, cellular regeneration, and anti-aging science. With over 20 years of research, 50 clinical trials, and 15 patents under his belt, Dr. Singh unpacks the groundbreaking science behind Urolithin A, a revolutionary postbiotic that boosts mitochondrial function, enhances immune system resilience, and combats chronic inflammation. This episode goes beyond cutting-edge science. Dr. Singh reveals practical, real-world strategies to combat “inflammaging”—the chronic, low-grade inflammation that accelerates aging. Learn how fasting, gut health, and mitochondrial boosters like Urolithin A can rejuvenate your cells, fight fatigue, and supercharge your energy, vitality, and longevity. Here’s what you’ll learn in this episode:  • What Urolithin A is and its role in mit

Are exosomes the planet’s ultimate healing tool?! In this episode, Dave Asprey sits down with Harvard-trained physician Dr. Edward Park to explore the groundbreaking science of exosomes. Dr. Park, a pioneer in regenerative medicine and author of Exosomes: Songs of Healing, explains how these tiny cellular messengers are revolutionizing health and longevity by bypassing the limitations of stem cells. BUT this episode isn’t just about cutting-edge science. Dr. Park also shares profound insights into life, resilience, and emotional well-being, offering advice that goes far beyond medicine. From the power of forgiveness to breaking free of limiting beliefs, his perspective blends science, spirituality, and practical wisdom for living a better life. Here’s what you’ll learn in this episode:  • How exosomes work and why they’re being called the future of regenerative medicine  • The key differences between exosomes and stem cells—and which is better for healing  • Real-life application

Is biohacking your sweat the secret to vitality? Dave Asprey dives into the transformative world of infrared saunas with Connie Zack, founder of Sunlighten and a 25-year innovator in the space. Together, they uncover how targeted light and heat therapy can unlock unparalleled health benefits, from detoxing heavy metals to energizing your body at the cellular level. Here’s what you’ll learn in this episode: • Why infrared saunas excel at detoxing heavy metals and toxins • How they mimic exercise to boost cardiovascular health and recovery • The science behind infrared’s impact on mitochondrial energy and longevity • Surprising benefits for gut health, inflammation, and hormone balance • Hacks to get the most out of your infrared sauna sessions Connie shares cutting-edge research and personal insights, offering practical ways to integrate infrared therapy into your routine. Whether you’re looking to recover faster, improve your mood, or support long-term health, this

What if you could command any room and set boundaries without saying a word? Dave Asprey sits down with Kasia Urbaniak, founder and CEO of The Academy—a trailblazing school where women learn the true principles of influence and authority. Kasia brings a unique and dynamic perspective, drawing on nearly two decades of experience that includes working as a professional Dominatrix, practicing Taoist alchemy in one of China’s oldest female-led monasteries, and earning certifications across disciplines like Medical Qi Gong and Systemic Constellations. Here’s what you’ll learn in this episode: • How to set clear, unbreakable boundaries in any situation • Techniques for wielding influence without sacrificing integrity • Tools to reclaim inner authority and navigate life with confidence • Practical strategies for handling power dynamics in relationships, work, and beyond Kasia’s methods have empowered over 4,000 women worldwide to step into leadership roles in every sphere, from per

Is unlocking the full potential of your brain even possible, or just a myth from the movie Limitless? In this eye-opening episode, neuroscientist and author Dr. Mithu Storoni joins Dave to dive deep into the science of brain optimization for hyper-efficient work performance. Together, they break down the surprising roles of astrocytes in supporting neurons, the influence of the brain’s “blue dot” region (the locus coeruleus) on focus and mental clarity, and how harnessing neuroplasticity can lead to improved cognitive efficiency and resilience in high-stress environments. Get ready to discover actionable science-backed hacks for enhancing work productivity and maintaining focus—even in the face of constant distractions. Dr. Storoni also explains how optimizing your breathing rhythm, managing your brain’s arousal state, and tapping into the natural flow of ultradian rhythms can dramatically improve your mental output. Whether you’re looking to elevate your workflow, supercharge your mental perfo

What if the keys to an extraordinary life lie in choices most people wouldn’t dare to make? In this iconic, unearthed episode, best-selling author and performance pioneer Tim Ferriss joins Dave Asprey to spill the unfiltered truth on smart drugs, insect protein, and the surprising links between sex, creativity, and high performance. They dig into cutting-edge topics still sparking curiosity today: the calculated risks and rewards of smart drugs, the future-forward benefits of insect protein, and how unconventional habits fuel creativity and peak performance. Tim candidly shares his personal protocols, from routine blood testing to strategic supplementation, all rooted in his philosophy that “the dose makes the poison.” As a powerful wrap-up, Tim lays out his top three life principles for real success: choosing high-caliber people, focusing on those who “get it,” and setting audacious, even wild, goals. Whether you’re biohacking or simply intrigued, this episode delivers timeless insights and bo

What if everything you believe about happiness is wrong? In this episode, Harvard professor and world-renowned happiness expert Arthur Brooks joins Dave Asprey to unlock the secrets of real happiness, revealing the science behind joy, resilience, and lasting fulfillment. As a bestselling author and co-author with Oprah Winfrey of Build the Life You Want, Arthur has spent decades helping people rethink happiness through a blend of psychology, neuroscience, and ancient wisdom. Together, Dave and Arthur explore eye-opening topics like the “reverse bucket list,” why dopamine-driven goals often lead to disappointment, and how embracing discomfort can actually create deeper contentment. Arthur dives into why our common pursuits of fame, wealth, and success often fall short, and shares powerful strategies for mastering what’s within our control, building resilience, and finding meaning in life’s simplest moments. From managing dopamine to harnessing the power of small wins, this episode offers science

Explore the science and potential of hypnosis as Dr. David Spiegel, Stanford’s leading expert in mind-body medicine, joins Dave Asprey to reveal how hypnosis can radically enhance cognition, mental clarity, and resilience. In this episode of The Human Upgrade, you’ll learn how hypnosis influences the brain’s most vital networks, including the default mode network and executive control, to break mental barriers and amplify focus, perception, and healing. Discover how hypnosis, unlike traditional meditation or neurofeedback, accelerates response times, manages pain, and even helps alleviate PTSD. Dr. Spiegel shares stories of patients overcoming chronic pain and trauma through self-hypnosis, and details the mechanisms that make hypnosis a powerful tool for emotional and physical transformation. Dive into the fascinating brain science behind the practice, from theta brainwave induction to deep sensory modulation, and learn simple self-hypnosis techniques that can elevate mental performance, improve sle

Unlock the mastermind secrets to cognitive enhancement as Dave Asprey shares his ultimate brain-boosting biohacks in this powerful episode of The Human Upgrade. Discover how Dave elevated his IQ, reversed Asperger’s, and overcame brain fog through advanced neurofeedback, BDNF-boosting supplements, mitochondrial enhancers, and the power of the groundbreaking 40 Years of Zen program. Explore revolutionary techniques, from ancient meditation practices to modern nootropics and smart drugs, all designed to amplify memory, focus, and resilience. Learn the science behind cognitive enhancement, from ketones like C8 MCT oil to essential supplements like Vitamins D, K, A, and magnesium that fuel optimal brain function. If you’re seeking proven methods to enhance neuroplasticity, boost mental endurance, or reduce brain fog, this episode is packed with actionable insights. Whether you’re aiming to maximize mental performance or unlock the latest in brain science, Dave’s mastermind approach offers a comprehensiv

Unlock the secret to cellular detox and discover how to cleanse your body from the inside out with Dave Asprey and Jessica Berman in this episode of The Human Upgrade. Explore cutting-edge detox strategies using phosphatidylcholine, Tudca, and butyrate, three powerful molecules designed to remove toxins, microplastics, and endocrine disruptors from your system. Jessica, co-owner of BodyBio, reveals how these products support not just detoxification, but also optimize mitochondrial function, enhance brain performance, and improve overall cellular health. From phosphatidylcholine’s ability to restore cell membranes to Tudca’s role in liver health, you’ll learn how to protect yourself from the daily onslaught of environmental toxins that can harm your longevity and vitality. If you’ve been searching for how to reduce your toxic load, flush out microplastics, or boost cognitive function, this episode is packed with actionable insights. Whether you’re a biohacker looking to enhance your cellular resilien

Step into the future of sports performance with The Human Upgrade as Dave Asprey and Aron D’Souza, founder of the Enhanced Games, uncover the controversial world of steroids, gene therapy, peptides, and human enhancement. In this groundbreaking episode, they explore how athletes can push the boundaries of physical and mental performance by embracing cutting-edge science once banned by traditional sports bodies like the Olympics. Discover why the Enhanced Games are redefining fairness in athletics, allowing competitors to use biohacking and performance-enhancing technologies to unlock new levels of strength, speed, and recovery. Aron breaks down the ethical dilemmas, the science behind enhancements, and why athletes should have full control over their bodies and biology. From synthetic growth hormones to the latest in gene therapy, this episode dives deep into the future of sports innovation. Whether you’re fascinated by the world of biohacking, curious about the next big revolution in sports, or wan

Unlock the power of continuous glucose monitoring (CGM) and transform your health in this eye-opening episode with Dave Asprey. Discover why tracking your blood sugar 24/7 isn’t just for diabetics—it’s the key to unlocking peak health, optimizing your metabolism, and preventing chronic diseases. Joined by Levels founder and biohacker Josh Clemente, Dave dives into the real science behind CGMs and how they provide unparalleled insights into how your diet, sleep, and exercise affect your blood glucose. You’ll learn how glucose spikes are linked to aging, inflammation, and energy crashes, and why keeping your blood sugar stable can help you boost mental clarity, enhance longevity, and even prevent conditions like diabetes and heart disease. Josh reveals the engineering mindset behind building Levels and how this game-changing technology is revolutionizing the way we understand metabolic health. With insider data from 50,000+ users, you’ll discover how simple lifestyle tweaks—like post-meal walks, sleep

Get ready to discover the true superfoods that can transform your health—starting with spirulina and chlorella. In this dynamic and thought-provoking episode, Dave Asprey welcomes Catharine Arnston, founder of ENERGYbits, to dive deep into the world of algae and its incredible potential to boost energy, detox the body, and support longevity. First, we challenge the myths around trendy “superfoods” and reveal why algae, particularly spirulina and chlorella, reign supreme for mitochondrial health and cellular energy. Catharine shares her 15 years of research on algae, explaining how it protects your cells, enhances brain function, and even supports cancer prevention. Next, we explore cutting-edge science on how algae supercharge mitochondrial performance, with Catharine revealing new clinical trial data that shows a 20% boost in mitochondrial function in just seven days. Finally, we break down the real-life impacts—improved brainpower, glowing skin, and detoxified cells—showing how this powerhous

Today, we’re diving into the age old question, what is the purpose of your life? We chat about the science behind emotional intelligence with Dr. John Demartini, creator of the groundbreaking Demartini Method. In this thought-provoking episode, Dr. Demartini reveals how his unique approach to personal development and emotional mastery can help you uncover your highest values and transcend emotional chaos. We explore how the quality of the questions you ask shapes the quality of your life, providing a roadmap to unlock your fullest potential. First, we dig into the hidden order of the universe, showing how the Demartini Method guides you to balance emotion, intuition, and inspiration for greater control and fulfillment in life. Then, we break down Dr. Demartini’s journey—overcoming learning challenges, mastering the mind-body connection, and developing a method that has transformed lives around the globe. Finally, Dr. Demartini shares actionable strategies for tapping into your innate brill

Today, we’re unlocking the full potential of your brain—starting with Bryan Johnson’s Blueprint for longevity and brain optimization. We’re revisiting our conversation with Bryan, the creator of the Don’t Die movement (among many other things), to explore how his groundbreaking approach to brain health and biohacking is reshaping the future of longevity. First, we dive into Bryan’s mission to make brain monitoring as easy as tracking blood glucose, using his Blueprint protocol to measure and optimize cognitive performance for better health and wellness. Then, we tackle the deeper side of biohacking—longevity, societal reactions to living longer, and how to handle critics when you’re pushing the limits of human potential. Finally, Bryan shares his personal journey—investing $80M into brain science, building the Blueprint for optimal living, and discovering the power of community and lifelong friendships for a long, vibrant life. This episode will change the way you think about brain health