Chi Podcasts

An-Dinh Nguyen interviews Avi Ma’ayan of Icahn School of Medicine at Mount Sinai on February 20, 2014. Dr. Ma’ayan will be a featured speaker during the shared session for the Systems Pharmacology and Cancer Informatics meetings at Bio-IT World Conference & Expo 2014, April 29-May 1 in Boston, MA. Topics include the emergence of systems biology in drug research, promising datasets that can accelerate drug discovery and personalized medicine, methods for extracting knowledge from data, the potential research impact of systems pharmacology and more. Join Dr. Ma'ayan and a focused group of Systems Pharmacology Researchers at Bio-IT World 2014. Learn more about the program at http://www.Bio-ITWorldExpo.com/Systems-Pharmacology

Anjani Shah, Ph.D., Conference Director, Cambridge Healthtech Institute, interviews Dr. Nhut Diep of Forest Laboratories on February 19, 2014. Dr. Diep will be speaking during the 7th Annual 'Efficient Process Chemistry' conference taking place May 22-23, 2014 as part of CHI's World Pharma Congress May 21-23 in Boston, MA. Efforts to identify a scalable process for preparing DPP-IV inhibitor compounds (diabetes therapeutic) led to the discovery of several useful transformations, including the asymmetric lithiation-boronation of the Boc-pyrrolidine that provided a single compound; the development of a streamline-telescope coupling reaction and workup which led to a robust crystallization/purification method.

Nandini Kashyap interviews Dr. Robert A. Bellantone of Long Island University on February 17, 2014. Dr. Bellantone will be speaking during the 2nd Annual Formulation and Drug Delivery conference taking place May 21-22, 2014 as part of World Pharma Congress in Boston, MA Poor Solubility, Bioavailability, Oral Drug delivery, Solubilization, Formulation material science, Solid state characterization, Dissolution Prediction and Experimentation, Drug and Product stability, Drug form stability, In vitro-In vivo correlation (IVIVC), Excipient-water interaction, Excipient drug interaction

An-Dinh Nguyen interviews William Telford of Sanofi on February 14, 2014. Mr. Telford will be a speaker during the shared session for the Data Security, IT Infrastructure – Hardware and Software Development meetings at Bio-IT World Conference & Expo 2014, April 29-May 1 in Boston, MA. Topics include the evolution of data security strategies for pharmaceutical companies and life science collaborators, data classification to determine risk levels and protections, security challenges unique to the pharma industry and more.

An-Dinh Nguyen interviews Ravi Madduri of University of Chicago and Argonne National Laboratory on February 10, 2014. Mr. Madduri will be a speaker during the shared session for the Cloud Computing and Next-Gen Sequencing Informatics meetings at Bio-IT World Conference & Expo 2014, April 29-May 1 in Boston, MA. Topics include the improvement of large-scale NGS analysis on the cloud, data management challenges life science researchers face, strategies and technologies for increasing scientists’ productivity and more.

An-Dinh Nguyen interviews Hugo Geerts of In Silico Biosciences and University of Pennsylvania on February 7, 2014. Dr. Geerts will be a speaker during the Systems Pharmacology conference at Bio-IT World Conference & Expo 2014, April 29-May 1 in Boston, MA. Topics include the limitations of translating outcomes from models for clinical utility, the application of computer-based methods to pharmaceutical R&D to improve predictability of clinical trials, the complexities of researching and developing drug therapies for the central nervous system and more.

Nandini Kashyap interviews Dr. William P. Beierschmitt, Ph.D., DABT, FATS, Regulatory Strategy Lead at Pfizer on December 20, 2013. Dr. Beierschmitt will be speaking during the 2nd Annual Extractables and Leachable conference taking place January 16-17 as part of PepTalk, January 13-17 in Palm Springs, CA. Topics include early adoption of toxicological risk assessment, risk assessment strategy, patient safety, safety issues related to extractables and leachables, role of toxicologist, plastic single use bioreactors, single use systems, risk based assessment, extractable testing, flexible manufacturing, process and product development, BPOG, USP, PQRI, standardized E&L testing, predication of leachable, toxicity and safety.

Nandini Kashyap interviews Dr. Yasser Nashed-Samuel, Principal Scientist, Amgen on December 6, 2013. Dr. Yasser Nashed-Samuel will be speaking during the 2nd Annual Extractables and Leachable conference taking place Jan16-17 as part of PepTalk, January 13-17 in Palm Springs, CA. Topics include a case study on E&L from single use bioreactors, E&L impact on cell culture performance, plastic single use bioreactors, single use systems, risk based assessment, extractable testing, flexible manufacturing, process and product development, , BPOG, USP, PQRI, standardized E&L testing, predication of leachable, toxicity and safety.

Nandini Kashyap interviews T.N. Thompson, President, Millrock Technology on December 6, 2013. Mr. Thompson will be speaking during the 7th Annual Lyophilization and Emerging Drying Technologies conference taking place Jan15-16 as part of PepTalk, January 13-17 in Palm Springs, CA. Topics include freeze drying, process control and monitoring for the freezing and primary drying phases, cycle development and process control, controlled nucleation, heat flow, reduction in drying cycle’s time.

Nandini Kashyap interviews Dr. William J. Lambert of MedImmune on December 6, 2013. Dr. Lambert will be speaking during the 4th Annual Protein Device Combinations conference taking place Jan 15-16, 2014 as part of PepTalk, January 13-17 in Palm Springs, CA. Protein Delivery, large volume delivery, bolus injections, delivery devices such as pens and auto injectors for drug delivery, high viscosity injectors, protein device combinations, protein and peptide products, pen injectors, pen needles and auto-injectors for self-injection, integration of formation and devices.

Nandini Kashyap interviews Jeffrey Breit, Ph.D of Bend Research on November 15, 2013. Dr. Breit will be speaking during the Lyophilization and Emerging Drying Technologies conference at the PepTalk, January 13-17 in Palm Springs, CA. Topics include using a vaccine formulation development, room temperature stability, use of spray drying, emerging drying technologies

Nandini Kashyap interviews Prof. Thomas Laue of University of New Hampshire on November 19, 2013. Prof. Laue will be speaking during the Protein Aggregation and Emerging Analytical Tools conference at the PepTalk, January 13-17 in Palm Springs, CA. Topics include protein aggregation, mechanism of protein aggregation, non-covalent interactions, hydrophobic effect, dipole-dipole interactions, effect of viscosity, development of analytical tools for aggregate detection, progress in the field of protein aggregation.

Nandini Kashyap interviews Jeffrey Breit, Ph.D of Bend Research on November 15, 2013. Dr. Breit will be speaking during the Lyophilization and Emerging Drying Technologies conference at the PepTalk, January 13-17 in Palm Springs, CA. Topics include using a vaccine formulation development, room temperature stability, use of spray drying, emerging drying technologies.

An-Dinh Nguyen interviews Sriram Kosuri of UCLA on November 11, 2013. Dr. Kosuri will be a keynote speaker during the Engineering Genes, Vectors, Constructs and Clones conference at PepTalk 2014, January 13-17 in Palm Springs, CA. Topics include the effect of codon usage on protein expression, the reliance on bacteria for biological engineering research, new tools like CRISPR for studying more eukaryotic systems, next-generation gene synthesis, work at the Wyss Institute and more.

An-Dinh Nguyen interviews Zhimei Du of Amgen on November 1, 2013. Dr. Du will be speaking during the Recombinant Protein Expression and Production conference at PepTalk 2014, January 13-17 in Palm Springs, CA. Topics include unfolded protein response, pathways for increasing recombinant protein production and expression yield, understanding cell status, UPR’s dynamic nature and cell line development at Amgen.

Lab-on-a-chip (LOC) devices have a tremendous potential for revolutionizing personal health. In developing countries, mobile diagnostics provide immediate diagnosis in the field, and in the U.S., patients and consumers can have greater access to traditionally complex diagnostics. CHI recently spoke with Dr. Samuel Sia of Columbia University about his latest projects at Columbia and the evolution of microfluidic technology. Dr. Sia also discusses how he sees mobile diagnostics playing a role in the future of medicine.

An-Dinh Nguyen interviews Sabine Geisse, Ph.D., Director/NLS, Novartis Institutes for BioMedical Research on October 31, 2013. Dr. Geisse will be a keynote speaker during the Transient Protein Production conference at PepTalk 2014, January 13-17 in Palm Springs, CA. Topics include the importance of considering cellular environments when working on genes and molecular biology, the evolution of biotechnology, recombinant production of increasingly complex biomolecules and more.

An-Dinh Nguyen interviews Joseph Kittle of Ohio University and Molecular Technologies Laboratories, LLC on October 30, 2013. Dr. Kittle will be a speaker during the Engineering Genes, Vectors, Constructs and Clones conference at PepTalk 2014, January 13-17 in Palm Springs, CA. Topics include problems with plasma-based protein expression, using engineered bacteria and chromosomally inserted genes, integrating current biotech industry knowledge with academic biochemistry and molecular engineering instruction and more.

An-Dinh Nguyen interviews Zoltan Szallasi of Harvard Medical School and Danish Technical University on 23 October 2013. Dr. Szallasi will be speaking during the Genome Informatics conference at the Clinical Genomics & Informatics Europe Conference & Expo on 4-6 December, in Lisbon, Portugal. Topics include: • Clinical Validation and Analysis of Cancer Genomic Data • Computational and Experimental Methods for Detecting Genomic Instability • Quantifying Homologous Recombination in Tumor Biopsies • Platinum Sensitivity in Breast Cancer • Adapting to Next-Generation Sequencing

An-Dinh Nguyen interviews Anne Cambon-Thomsen of CNRS on 23 October 2013. Dr. Cambon-Thomsen will be a keynote speaker during the Genome Informatics conference at the Clinical Genomics & Informatics Europe Conference & Expo on 4-6 December, in Lisbon, Portugal. Topics include: • Interdisciplinary Aspects of Public Health Research • Ethical, Societal and Legal Issues • Applications of Immunogenetics Research • Genomic Data Sharing vs. Privacy Protection