Paleo Baby

Catherine Crofts is a New Zealand community-based clinical pharmacist who firmly believes in using the lowest dose of the least number of medications to treat disease. After 17 years of practice, she feels more like a “disease management specialist” than a health professional. Together with Caryn Zinn, Mark Wheldon, and Grant Schofield, Catherine is the author of Hyperinsulinemia: A unifying theory of chronic disease? Catherine blogs at Lifestyle Before Medication. Catherine will soon be known as Dr. Crofts after successfully defending her Ph.D. thesis where she analysed the oral glucose and insulin tolerance data of Dr. Joseph Kraft. Catherine will talk more about that work and why fasting insulin is a useless biomarker in the upcoming Keto Summit, in this interview we focus on the role of insulin resistance in dementia. Here’s the outline of this interview with Catherine Crofts: 0:00:42    Professor Grant Schofield and Dr. Caryn Zinn. 0:00:47    Dr. Joseph Kraft from Chicago. Book: Diabetes Epidemic &

I couldn’t help laughing when former UFC fighter Kyle Kingsbury described the trouble he was having deadlifting 525 lb when 495 came so easily. 180 is a problem for me! The ketogenic diet has removed Kyle’s “low gear”, but the sacrifice is worth it because, in the ketogenic state, Kyle enjoys an enormous cognitive benefit and less systemic inflammation. Having suffered two orbital fractures that ultimately lead to his retirement, I wonder if Kyle is an example of how ketosis can help with traumatic brain injury. Do not supplement with raw potato starch! Kyle and his wife are yet further examples of people that didn’t do well supplementing with raw potato starch. Kyle noticed changes in his immune system that lead to an increase in sickness, and his wife Natasha gained body fat. Both were able to resolve those issues following Grace Liu’s plan that included psyllium, acacia, and inulin-FOS together with a bifidobacteria probiotic. Here’s the outline of this interview with Kyle Kingsbury 0:01:06    Kyle is 6'3.

Imagine your name is Bob. You’re 47 years old, you have a beautiful wife, two wonderful kids, a lovely dog and a career you enjoy. Life is great is except for the nagging pain in your right pinky finger. It started as a minor irritation but now has gotten to the point where it’s affecting your work and your sleep. As you lay tossing and turning one night, all you can think about is the pain. Then suddenly you decide it’s time to get up and take action. You kiss your wife and sneak out the bedroom. The dog is confused and follows you downstairs and into the kitchen. You open up the lid of your laptop and open a new browser window. Google appears. What are you going to search for? Doctor [Your Name Here] Ultrawellness? Optimal Health Nutrition Coach? Of course not. You’re going to search for “right pinky finger pain” or some variation of those words. So why is then that so many practitioners, good ones, create websites that are all about themselves? You know the site I mean. The one with the picture of the prac

The Information Age brought with it’s ugly stepsister named Confusion. Never was this more true than for the information and misinformation surrounding vitamin D, sunscreen, and cancer. Not getting burned makes intuitive sense, but will slathering on the sunscreen cause vitamin D deficiency? Could vitamin D deficiency be causing the cancer that the sunscreen is supposed to be protecting against? How much of a concern is skin cancer anyway? Do we need to worry about toxic chemicals in sunscreen? What type of sunscreen is best? Join Dr. Tommy Wood and me in this podcast interview for everything you need to know about to protect your skin in the performance and longevity. Also check out our article: Optimizing Vitamin D for Athletic Performance. When Tommy and I recorded this podcast I was using the Badger brand suntan cream, since then I’ve switch to using Rocket Pure. Here’s the outline of this interview with Dr. Tommy Wood 0:04:19    What is vitamin D (25-OH-D)? 0:05:37    Made using UVB radiation from the s

I asked David Aiello, President BioAdvantex Pharma Inc.: of all the molecules, why study and productise N-acetylcysteine? “That makes me think of another question, why did you marry that woman? You become fascinated with something, and your mind sees forward. I saw this as a huge business and scientific project with such a broad scope to help people. We didn't even understand the scope way back then.” Paracetamol-induced acute liver failure. In the US and UK, paracetamol (acetaminophen) toxicity is the most common cause of acute liver failure. When taken in normal therapeutic doses, paracetamol is safe. The cytochrome P450 enzymes convert approximately 5% of paracetamol to a highly reactive intermediary metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). Under normal conditions, NAPQI is detoxified by conjugation with glutathione. In cases of overdose, the pathways become saturated, leading to more NAPQI. Liver supplies of glutathione become depleted, and NAPQI remains in its toxic form in the liver, reacting w

I sit too much. When I’m not sitting at my desk, I’m sitting on my bike. As a mountain biker, I stand more than some cyclists, but still. The ways in which I move my body are predictable and very repetitive. I almost never move from side to side, and I expend vast amounts of energy spinning small circles with my feet. Have humans evolved to move like this? I doubt it. I know that if I’m not careful, I start to develop niggling lower back pain and piriformis syndrome. Obstacle racing then, or at least the training for it, appeals to me because of the variety. The movement that elite Spartan racer Elijah Markstrom describes in this interview is a lot like what I think I need to do as a mountain biker looking to add variety to my workouts. James Wilson talked about similar exercises to improve strength and mobility previously on my podcast. When two people you respect talk about getting results using the same tactics, you’re on to something. Elijah Markstrom is a health nut and fitness enthusiast. Elijah spends

Could you afford to spend $250,000 on an education? No, neither could I. How lucky are we then that people like Drs. Mike T. Nelson Ph.D. and Dr. Brad Dieter Ph.D are willing to distill what they’ve learned into a $250 training course? Over the past two years, I’ve done all kinds of biology, biochemistry, physiology, functional medicine, nutrition and fitness massively open online training courses and I’ve loved them all. Educators pour their heart and soul into these resources and we should take full advantage. The Eat to Perform certification course covers the basic mechanisms of exercise physiology and the interactions between nutrition and human performance. The material is delivered via video and PDF and the exam is done online. A Facebook support group and lifetime updates are included in the price. Sign up now, it’s a steal! Dr. Tommy Wood, my wife and food scientist Julia, and I have got together to create a hypoallergenic MCT oil powdered with a special bionic fibre. Find out more at phatfibre.com an

“I’ll sleep when I’m dead,” so the lyric goes. If you don’t sleep you will be dead sooner is more true to life: Sleep improves everything. I mean, literally everything. I've not found a single thing that I can't tie to sleep being a major component of. And if you aren't sleeping well, you're just at risk for more of anything bad. Anything bad. --Dr. Kirk Parsley, MD, sleep expert and advisor to the Navy SEALs. Selling sleep should be like selling sex, so why is it so hard for people to do? Two reasons: Humans are the only animals with electricity, and we’ve used it to maximal effect for disrupting our normal circadian rhythms. It’s not that people won’t sleep, the problem is they can’t sleep. Time is money and shift working is a sad fact of life. The main thing you must do to get better sleep is appreciate its importance. I want you to buy into the idea of sleep and strive for it as you would any other goal. The rest is relatively straightforward, and that’s what Kirk and I cover in this podcast interview.

Ketogenic junk food is coming, and it threatens to send the second low-carbohydrate revolution to the same place the first one ended up. That would be a terrible shame because high-fat, low-carb, moderate protein diets have so much to offer for weight loss, metabolic syndrome, athletic and cognitive performance, possibly even cancer. What can we do? Learn to cook. Prioritise food preparation. Just eat real food. Jeremy Hendon is an author, speaker, entrepreneur, digital nomad, friend, mentor and co-author of The Essential Keto Cookbook. I wrote the foreword to the book, and the day before Jeremy and I recorded this interview, my wife Julia made two of the recipes. Pork and Cashew Stir-Fry INGREDIENTS 1/2 lb (225 g) pork tenderloin, sliced thin 1 egg, whisked 1 bell pepper, diced 1 onion, diced 1 cup (140 g) cashews 1 Tablespoon (5 g) fresh ginger, grated 3 cloves of garlic, minced 1 teaspoon (5 ml) Chinese chili oil (see page 185 for recipe) (optional) 1 Tablespoon (15 ml) sesame oil (optional) 2 Tablespoon

In my early twenties, I tore a carotid artery out of my neck in a motorcycle accident. The emergency procedure that followed undoubtedly saved my life and from that point forward I had no time to listen to people complaining about the limitations of the nationalised health care that exists in the UK. In my thirties, the same system of evidence-based medicine let me down badly, and in the end, it was a chiropractor who describes himself as “the least evidence-driven person he knows” that turned my life around. Now I’m slightly confused. I am aware that the evidence-based system has a lot to offer, but I don’t feel I can use it effectively without the assistance of someone like Dr. Tommy Wood. Why? The system is in crisis. The system is in crisis in part because of the sheer volume of evidence being generated, much of which is unreproducible or misappropriated by vested interests. Building a meta-analysis atop of this shoddy foundation does little to clarify the situation. Animal and cell models. Are used as su

Imagine you’re in the pub and you’ve just bumped into your friend Mario Roxas. Mario happens to be a naturopathic doctor and the director of research and development at Thorne, the Rolls Royce of supplement companies. Wouldn’t you want to know what supplements Mario takes? Me too, and so I couldn’t resist making that my first question. But what is it that makes Thorne Research different? Why not buy your supplements from Costco? Two reasons: research and quality. Thorne employ a team of medical and naturopathic doctor scientists that spend their time studying the scientific literature on the lookout for evidence supporting the decision to manufacturer a specific supplement. Secondly, there’s quality. Thorne cater to the sensitive customer likely to experience allergic reactions. The raw materials used to make a supplement originate from trusted sources, but Thorne validate the content of all their supplements no less than three times during the manufacturing process. Surprisingly, the FDA laws only require a

Three years ago I went through round after round of blood testing until eventually I realised that the doctor was following a procedure laid out in a flow chart. Heck, he even showed me the flow chart. Two months and thousands of dollars of insurance deductibles later I was no closer to understanding the underlying cause of my fatigue, insomnia, brain fog and other symptoms. My doctor seemed somewhat willing to run any blood test I wanted but he held the results very close to his chest. Everything was normal, and the Google searches I made in an attempt to understand better my results yielded nothing useful. It’s not that sodium and potassium on a blood chemistry don’t mean anything, they do, it’s that you won’t ever be able to figure it out without some help. When I finally admitted defeat and looked outside the network of doctors willing to accept the insurance that was costing me a fortune and getting me nowhere fast, I found someone who wanted to run a urinary organic acids test. What is an organic acid?

Run a blood test, find low levels of a hormone. Prescribe synthetic version of said hormone. Two weeks later your patient is back with a slightly different set of symptoms. Run another blood test, prescribe another hormone. If there's too much, block it, if there isn't enough, just add more. Rinse and repeat for hypothalamic pituitary adrenal, thyroid and gonadal axes. Refer out to a gastroenterologist for chronic diarrhoea. Gastroenterologist diagnosis is “irritable bowel syndrome”, says it’s nothing to do with diet, suggests colonoscopy, anti-inflammatory drugs, possible surgery. This sounds like a parody. But this is what happened to me, and it’s still happening to other athletes. Finding a better solution inspired me to quit my day job as a computer programmer at a hedge fund and start a new business with my wife (a food scientist) and a medical doctor. 2015 was our first full year in practice. At the time of recording, we’ve helped over 600 athletes with their diet and lifestyle. We’ve gotten great resul

My sister called me looking for help with her son’s science project. “William has some questions about the paleo diet and how it affects the health of cells.” It soon emerged that he had a particular list of questions that he wanted answering, and initially I thought I should do some research and answer them to the best of my ability just as I would with any list sent to me. The longer I thought about the list of questions, the more I thought it looked like the outline to a great podcast, and who better than Dr. Tommy Wood to provide the answers? But why care about cellular health in the first place? We tend to think of health in terms of big things, but a living organism is just a collection of organ systems. An organ system is a set of organs, and those organs are made up of tissue. Drilling down beyond the tissue, we arrive at the smallest level of organisation able to sustain life: the cell. We’re all just a big bag of cells, trillions and trillions of them! Happy cells make for happy bodies, so it makes

Something wonderful is happening in Iceland, and it has nothing to do with geysers, volcanoes or even Björk. A group of medical doctors led by Dr. Guðmundur Jóhannsson are actively engaging in a discussion of the utility of high-fat, low-carb, moderate-protein diets for treating some of the chronic health complaints they see in practice. Imagine for a moment you’re a doctor working in emergency care. How frustrating must it be only to see the end stages of the diseases caused by insulin resistance? You’d be just like a mechanic working on the damage done to an engine caused by failure to change the oil. Not only is the situation potentially preventable, it’s also expensive enough to bring down the entire national health service. My question is why Iceland? Is it the manageable size? Dr. Jóhannsson has been able to bring around 200 doctors to the discussion on a Facebook group. Doesn’t sound like a lot, but that’s a significant proportion of all the doctors on the island. Is it because they have nationalised h

Cancer is like a computer program gone wrong, the kernel panic of the human body. Unfortunately, we have no reboot button, and so cancer is the most serious of diseases. This year, almost six hundred thousand Americans will die from cancer. Despite the fact that cancer receives more NIH funding than any other illness, the death rates remain the same as in the 1950s. Tripping Over the Truth: The Return of the Metabolic Theory of Cancer tells the story of molecular biologist and science writer Travis Christofferson’s journey to discover why cancer has remained so elusive. The central theme of the book is that we’ve fundamentally mischaracterized the origin of cancer. Most scientists hold to the belief that cancer is a genetic disease, Travis explores the idea that cancer is, in fact, a disease of damaged metabolism. The metabolic theory of cancer stems from Nobel laureate Otto Warburg’s observation in 1924 that cancer cells lack the ability to produce energy using anything other than an ancient and inefficient

Cortisol: the emergency responder hormone that when chronically elevated, makes you fat, stupid and unsexy. Nobody wants an excess of cortisol, but like all things in physiology there’s a sweet spot; low cortisol doesn’t feel right either. Which you have? Symptoms of high cortisol Symptoms of low cortisol Fatigue Extreme fatigue Muscle weakness Muscle or joint pains Depression, anxiety and irritability Depression, irritability Loss of emotional control Salt craving Cognitive difficulties Abdominal pain New or worsened high blood pressure Low blood pressure, even fainting Glucose intolerance that may lead to diabetes Low blood sugar (hypoglycaemia) Headache Nausea, diarrhea or vomiting Bone loss, leading to fractures over time Weight loss and decreased appetite Source: Mayo Clinic Both sets of symptoms are very similar, in fact, all of these symptoms could be attributable to half the diseases known to man. The only way to know for sure what’s going on with your cortisol is to do the test. I tested over 500 end

Have you ever been trapped in a small meeting room with a guy in a grey shirt with sweat marks under the arms? The meeting has a clear agenda, but all you can think about is that smell. Yikes, just thinking about this is enough to make me want to take a shower, scrub my armpits and apply some deodorant. Is the problem an antiperspirant deodorant deficiency? Why have humans evolved to a strong revulsion complex to what is a normal human smell? Have artificial fragrances warped our sense of smell? It’s not normal For our teenage boys to smell of basil, lavender, and rich vanilla. It’s not normal for women to emanate Daisy Fresh, Peach Burst, Blossoming Orchid, Tropical Rush, and Berry Cool. These are all things that have been impressed upon us by the companies that make person care products, and I think it’s important that we are aware of it. Are you telling me I should stink? Yes, a little bit, sometimes. But also I want you to think about where the smell is coming from, and I want you to think about how the s

The monotone of an EKG machine detecting flatline. It doesn’t get any worse than that. For realtor Douglas Hilbert, the list of low points doesn’t end there. Doug filed bankruptcy at the age of 28, had his home foreclosed on, had two vehicles repossessed, lost multiple businesses, lost 130 “investment” properties and ended up in drug rehabilitation numerous times. Each day was a rollercoaster ride of caffeine and nicotine highs followed by alcohol induced lows. Back then, depression and anxiety were the norm. Now aged 37, Doug feels better than at any time in his life. So what did Doug do? Doug describes exactly what he did in his new book Letters to My Son: Choosing Yourself First, and I am honoured to get more than one mention. It starts with food. Doug had good results eating a low-carb paleo diet but has found a high-fat, low-carb, moderate protein ketogenic diet to be even better. If there’s one lesson to be learned, it’s just eat real food. Prioritising sleep. Our modern environments are seldom conduciv

Apple Frudel. Banana Chocolate Chip Bread. Cinnamon French Toast Bread. Blueberry Snack’N Waffle. Cocoa Puffs Cereal Bar. Cheerios Cereal Bar. Cinnamon Pop Tart. Strawberry Splash Pancake. Super Donut. All these “food” items were taken from the breakfast menu for my nephew’s school. Presumably an expert designed this menu because it bares the logo of ChooseMyPlate.gov. If you can't trust the experts, who can you trust? How do you protect yourself from misinformation that has the potential to hurt you and your children’s health? There is only one way, and that’s to learn how to evaluate scientific evidence and think critically. Danny Lennon is a nutrition educator and critical thinker, and his Sigma Nutrition podcast is a powerful platform. As you can probably tell from his accent, Danny is from Ireland. After completing a degree in biology and physics, Danny worked as a teacher for a while before returning to the University of Cork to complete a master’s degree in Nutrition Science. After failing to achieve