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This week — a new technology falls into the wrong hands. Pope Brock's book, Charlatan Penny Lane's documentary, Nuts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

For years, Dr. Richard Bedlack has hunted for a cure for ALS, a fatal degenerative disease. And then one day he builds a website called ALS Untangled. That's when strange things start to happen. Reported by Peter Andrey Smith and Reply All producer Sruthi Pinnamaneni. Further Reading The ALS Untangled website Dr. Richard Bedlack’s ALS Reversals website The PatientsLikeMe website The ALS TDI website Nelda Buss wrote a book, You Can Walk, about her experience, and she originally appeared on Fox in 1992 Eric Valor’s website Angelina Fanous’s reporting on VICE and The New York Times Peter Andrey Smith’s website Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week, updates on some of the stories we’ve done over the past year, some bonuses and surprises, some breakbeats, a motorcycle ride, and we take a glimpse into the future. Check out the amazing 2016 Reply All poster by Matt Lubchansky! The Episodes #56 Zardulu #64-67 On the Inside Parts I-IV #53 In the Desert #68 Vampire Rules #57 Milk Wanted #47 Quit Already! Lightning Round #76 Lost in a Cab #83 Voyage Into Pizzagate #60 A Simple Plan #61 Baby King #69 Disappeared #78 Very Quickly to the Drill Further Reading Illustrator Matt Lubchansky’s website is OVER HERE Singer/songwriter Matt Farley can be found on his website or on Spotify. Our theme song is by the Mysterious Breakmaster Cylinder. Our ad music is by Build Buildings. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Everybody has that one Facebook friend who just won’t stop posting their political opinions. This week, we talk to one of those Facebook friends, someone whose opinions got her into an enormous mess. Learn more about your ad choices. Visit podcastchoices.com/adchoices

A conspiracy theory, a pizza related map, and a website fighting for its very soul. Further Reading Bryan Menegus' great article, "Reddit is Tearing Itself Apart." An interview with Edgar Welch, the Pizzagate gunman. The Donald Subreddit If you have a question about a story we've reported this year, please email a voice memo of 30 seconds or less to replyall@gimletmedia.com with the subject line "updates." Learn more about your ad choices. Visit podcastchoices.com/adchoices

Alex and PJ take calls from anyone, about anything, for 48 hours straight. Thank Yous Adam Quinn (for setting up our phone system) Peter Nelson (for his excellent horn playing) The Mysterious Breakmaster Cylinder (for going above and beyond this week) Matt Farley Jorge Just Austin Thompson Build Buildings Everyone who called Learn more about your ad choices. Visit podcastchoices.com/adchoices

One man tries to unite America. One Frog threatens to tear it apart. Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week: a bitter Yes Yes No rivalry, and the return of 10 Minutes on Craigslist. Someone has gone missing. Further Reading The original tweet. Loss. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Thomas Oscar is an Australian teenager who tried to make the most boring Facebook group possible - a group where members pretend to be corporate drones in a non-existent office. The Facts Karen Duffin is a producer at This American Life. You can find more stories by Karen Duffin at her website. Our theme song is by the mysterious Breakmaster Cylinder. Our ad music is by Build Buildings. Further Reading You can check out the Stackswell and Co. Facebook page here. Read a story about Stackswell and Co. from Fast Company here. Learn more about your ad choices. Visit podcastchoices.com/adchoices

To reach a port, we must set sail. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Alex and PJ chase down the strangest tips from our Weird Ads hotline, and at the bottom of the rabbit hole they find the Mother of All AdWords Scams. Futher Reading David Segal's story on locksmiths The Ringfinders website Form to give feedback on specific ads Google's statement on our episode:  Our goal is to provide a great experience for the users, advertisers, and publishers that interact with our advertising products everyday. An important part of this work is listening to reactions—good, bad, and in-between—from our users about their experiences online. We appreciate this very much; it helps us make AdWords better. Bad ads are an industry-wide issue and we fight them with considerable fire-power: we’ve invested in best-in-class technology and built a global team of more than 1,000 googlers specifically dedicated to this effort. While this work has produced positive results—we disabled 780 million ads for violating our policies in 2015 alone—we understand this is an ongoing challenge for everyone and

Forty servers full of lost photos, a secret plan, and an unexpected rescue. Also, a Yes Yes No about a frog. Further Reading Hillary on Pepe Matt Furie (Pepe's creator) on Pepe Smugmug's statement on Picturelife Our Sponsors 99designs – Visit 99designs.com/reply to get a free $99 upgrade on your first design project. HPE - To learn more about how HPE can provide innovative and effective it solutions for your business go to HPE.com/gimlet. Wealthsimple – Investing made easy. Get your first $10,000 managed for free. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Liz lost her camera in a cab, so she went to the New York City Taxi website to submit it to their lost and found database. At least, that's what she thought she did. Alex investigates and finds a big business behind the success of a suspicious little website. Further Reading If you lose something in a cab in New York City, Call 311, or go to this website. The Department of Consumer Affairs encourages anyone who feels they have been misled by yellowcabnyc.com to file a complaint with DCA‎ online at nyc.gov/consumers or by calling 311.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Barry develops a small but very inconvenient health problem, which becomes so persistent and pernicious that it feels as if someone put a curse on him. Sruthi Pinnamaneni goes deep on a decades-long medical mystery. Lisa Sanders’ book, Every Patient Tells a Story. Lisa Sanders’ column, Diagnosis. Become a Gimlet Member to join our Q&A this Friday at 12PM EST! Listen to Reply All Executive Producer Tim Howard's latest release as Soltero! Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week, a story about people who start hearing voices in their heads. But, instead of trying to get rid of the voices, they try to make more. Reporter Laura Klivans has the story. Our Sponsors Mailchimp – Send better emails. Also visit Mailchimp’s new non-profit online store Freddieand.co. Fracture – Get 10% off, and don’t forget to mention Reply All in their one question survey. Squarespace – The easiest way to create a beautiful website, portfolio or online store. Use the offer code “REPLY” to get 10% off your first purchase. Learn more about your ad choices. Visit podcastchoices.com/adchoices

One twin decides to plug her internal organs directly into the internet so the other twin can monitor her. Plus, PJ and Alex talk to a listener whose heart was broken by last week's episode. Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week, a Yes Yes No about gorillas, conspiracy theories, and glitter. Further Reading See the original tweets on our Yes Yes No tumblr. Marina Joyce's YouTube Article on Marina Joyce Police tweeting about Marina Joyce Learn more about your ad choices. Visit podcastchoices.com/adchoices

Rachel was a faithful user of a photo storage website called Picturelife, until one day all of her photos disappeared. As she investigated, she realized that every Picturelife user was having the same problem. Alex tries to find out if there's any hope of getting her photos back. Also, a preview of the new Gimlet show, Science Vs! Subscribe to Science Vs. by clicking this link. Become a Gimlet Member by clicking this link. Learn more about your ad choices. Visit podcastchoices.com/adchoices

PJ dives into the world of military impostors and the vigilantes who hunt them. Plus, a dispatch from Dallas. Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week a man decides to sabotage the entire internet. Plus, PJ discovers the secret code he’s accidentally been speaking, and learns about the people who created it. Learn more about your ad choices. Visit podcastchoices.com/adchoices