Authentic Biochemistry
- Autor: Vários
- Narrador: Vários
- Editora: Podcast
- Duração: 434:45:48
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Sinopse
You have wisely landed upon Authentic Biochemistry, with Dr Daniel J Guerra, where published research and clinical science is interrogated.
Episódios
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![ImmunoEpigenetics 68. Closure on atherosclerosis and CVD linking transcription factors and membrane receptors to oxidation of PUFAs and oxysterol resulting in methylation of ABCG and SREB promoters]()
ImmunoEpigenetics 68. Closure on atherosclerosis and CVD linking transcription factors and membrane receptors to oxidation of PUFA's and oxysterol resulting in methylation of ABCG and SREB promoters
18/05/2023 Duração: 29minReferences Arterioscler Thromb Vasc Biol . 2021 Jan;41(1):153-166. Clinical Epigenetics 2021. volume 13, Article number: 7. https://www.sciencedirect.com/topics/immunology-and-microbiology/foam-cell --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
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![ImmunoEpigenetics 67. Pathobiochemical alteration of cholesterol oxides mediated via cytochrome P450 and dehydro -reductases link atherosclerosis and the CTX/SLO motor neuron diseases. DJGPhD]()
ImmunoEpigenetics 67. Pathobiochemical alteration of cholesterol oxides mediated via cytochrome P450 and dehydro -reductases link atherosclerosis and the CTX/SLO motor neuron diseases. DJGPhD
16/05/2023 Duração: 29minReferences JLR 2014 55(6) Pages 1165-1172. JLR 2018 59(6): 1058–1070. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
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![ImmunoEpigenetics 66. The NOX/PHOX/DUOX enzymes in atherosclerosis, thyroid hormonogenesis and thyroid tumorigenesis. An epigenetic telos from oxidized lipid to altered transcription patterns.DJGPhD.]()
ImmunoEpigenetics 66. The NOX/PHOX/DUOX enzymes in atherosclerosis, thyroid hormonogenesis and thyroid tumorigenesis. An epigenetic telos from oxidized lipid to altered transcription patterns.DJGPhD.
16/05/2023 Duração: 29minReferences PLoS ONE 2012. 7(4): e3440 Steroids 2021. Volume 172, August, 108854 Antioxidants 2019, 8(5), 126 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
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![ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis.]()
ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis.
14/05/2023 Duração: 30minReferences Free Radical Biology and Medicine Volume 71, June. Pages 1-15 Cardiovasc.Res. 2012 May 1; 94(2): 379–390. Int. J. Mol. Sci. 2020, 21(7), 2578; https://doi.org/10.3390/ijms21072578 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
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![ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means]()
ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means
12/05/2023 Duração: 30minReferences Free Radical Biology and Medicine 2014. Volume 71, June.Pages 1-15 J Mol Endocrinol. 2020 Nov; 65(4): R77–R90. REDOX and Cholesterol metabolism lectures-Dr Guerra --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites]()
ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites
10/05/2023 Duração: 29minReferences Cancers (Basel). 2019 May; 11(5): 678. Oncogene.2017 Mar 23; 36(12): 1607–1618 Dr Guerra's annotated lecture notes from graduate biochemistry course(s) --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics62.Macrophage training and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD]()
ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD
10/05/2023 Duração: 29minReferences Front. Cell Dev. Biol., 26 March2021 Sec. Molecular and Cellular Oncology Volume 9 Cancer Drug Resist 2020;3:762-74. Oncogene.2017 Mar 23; 36(12): 1607–1618 Front Immunol. 2020; 11: 1782. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability.]()
ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability.
09/05/2023 Duração: 29minReferences Dr Guerra Intermediary metabolic lecture notes-graduate biochemistry lecture archives Epigenetics. 2019; 14(12): 1183–1193. Drug Discov Today. 2017 Jan; 22(1): 186–193. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![Immunoepigenetics 60. LOH of PHLDA3 confers wt allelic methylation and loss of activity in pancreatic neuroendocrine tumorigenesis. DJGPhD.7May23 Authentic Biochemistry Podcast]()
Immunoepigenetics 60. LOH of PHLDA3 confers wt allelic methylation and loss of activity in pancreatic neuroendocrine tumorigenesis. DJGPhD.7May23 Authentic Biochemistry Podcast
07/05/2023 Duração: 29minReferences Int J Mol Sci. 2020 Jun; 21(11): 4098. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics59. The P53/AKT/PHLDA3 axis over tumorigenicity is controlled by endomembraneous targeting via glycerol lipid PhosphatidylInositol bis-phosphate (PIP2) phosphorylation to PIP3.5.12.23]()
ImmunoEpigenetics59. The P53/AKT/PHLDA3 axis over tumorigenicity is controlled by endomembraneous targeting via glycerol lipid PhosphatidylInositol bis-phosphate (PIP2) phosphorylation to PIP3.5.12.23
06/05/2023 Duração: 29minReferences Int J Mol Sci. 2020 Jun; 21(11): 4098. Authentic Biochemistry lectures :ImmunoEpigenetics 56-58 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics 58. Epigenetic mechanisms role in Loss of Heterozygosity (LOH) in TSGs advancing targeting of solid tumors via pharmacotherapeutic CAR-T cells. DJGPhD 27.4.23. Authentic Biochem.]()
ImmunoEpigenetics 58. Epigenetic mechanisms role in Loss of Heterozygosity (LOH) in TSG's advancing targeting of solid tumors via pharmacotherapeutic CAR-T cells. DJGPhD 27.4.23. Authentic Biochem.
28/04/2023 Duração: 29minReferences BMC Medical Genomics. 2015. volume 8, Article number 45. Journal for ImmunoTherapy of Cancer 2022;10:e003826. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics 57. Plasmacytoid dendritic cell neoplasias and the CAR-T cell tumor microenvironment exposure altering epigenetic TF regulation leading to diverse differentiation. DJGPhD.20.4.23]()
ImmunoEpigenetics 57. Plasmacytoid dendritic cell neoplasias and the CAR-T cell tumor microenvironment exposure altering epigenetic TF regulation leading to diverse differentiation. DJGPhD.20.4.23
21/04/2023 Duração: 30minReferences Current Oncology Reports. 2020. 1534-6269, May 15, Vol. 22, Issue 6. Cell. 2021 Dec 9; 184(25):6081–6100.e26. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics 56. Dendritic cell immunobiochemistry introductions. DJGPhD. Authentic Biochemistry 15.4.23]()
ImmunoEpigenetics 56. Dendritic cell immunobiochemistry introductions. DJGPhD. Authentic Biochemistry 15.4.23
15/04/2023 Duração: 28minReferences Autoimmunity. 2012 Aug;45(5):333-47 Clinical and Experimental Rheumatology 2019: One year in review 2019: systemic lupus erythematosus Trends in Immunology, 2021-01-01, Volume 42, Issue 1, Pages 59-75 Annu. Rev. Immunol. 2000. 18:767–811 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics55. ILC and Treg differentiation is mediated by acetylation and methylation epigenegtic authorship at discrete TF binding site domains.DJGPhD.14.4.23. Authentic Biochemistry]()
ImmunoEpigenetics55. ILC and Treg differentiation is mediated by acetylation and methylation epigenegtic authorship at discrete TF binding site domains.DJGPhD.14.4.23. Authentic Biochemistry
14/04/2023 Duração: 28minReferences Cell Reports 2015 10, 2043-2054DOI ID2_HUMAN,Q02363 Experimental & Molecular Medicine 2019. volume 51, Article number: 80. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![Immunoepigenetics 54. Macrophages, T lymphocytes and neutrophils each comply with epigenetic alterations to mediate the inflammatory response. DJGPhD.12April.2023.Authentic Biochemistry]()
Immunoepigenetics 54. Macrophages, T lymphocytes and neutrophils each comply with epigenetic alterations to mediate the inflammatory response. DJGPhD.12April.2023.Authentic Biochemistry
13/04/2023 Duração: 29minReferences Guerra's notes --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics 53.The metaphysics of biochemical control within epigenetic alteration of gene expression as obtained in macrophage mediated immune activation. DJGPhD.7April23Authentic Biochem]()
ImmunoEpigenetics 53.The metaphysics of biochemical control within epigenetic alteration of gene expression as obtained in macrophage mediated immune activation. DJGPhD.7April23'Authentic Biochem
07/04/2023 Duração: 29minReferences Dr Guerra's lecture notes-Immunology DJGPhD writings on Middle Platonist Metaphysics in Biochemistry: unpublished Curr Opin Biotechnol. 2020 Jun; 63: 111–117 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics 52. Integration of intermediary metabolism with epigenetic modification of immune cell activation and proliferation.DJGPhD. 5April23. Authentic Biochemistry Podcast.]()
ImmunoEpigenetics 52. Integration of intermediary metabolism with epigenetic modification of immune cell activation and proliferation.DJGPhD. 5April23. Authentic Biochemistry Podcast.
05/04/2023 Duração: 30minReferences Curr Opin Biotechnol. 2020 Jun; 63: 111–117 Epigenomics. 2019. VOL. 11, NO. 68 May Front.Genet., 23 October 2018 Sec. Epigenomics and Epigenetics Volume 9. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics 51. The Glutamine contribution to tumor bioenergetics and lipogenesis and the role of storage TAG in macrophage pro-inflammation. DJGPhD. 29.3.23]()
ImmunoEpigenetics 51. The Glutamine contribution to tumor bioenergetics and lipogenesis and the role of storage TAG in macrophage pro-inflammation. DJGPhD. 29.3.23
30/03/2023 Duração: 27minReferences Nature Communications 2020.volume 11, Article number: 4107. Nutrire 2016. volume 41, Article number: 14 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics 50. Malic Enzyme serves as a cytosolic circuit to generate pyruvate from glutamine to drive cancer cell division by altering TCA flux and indirectly, cell cycle progression.DJGPhD]()
ImmunoEpigenetics 50. Malic Enzyme serves as a cytosolic circuit to generate pyruvate from glutamine to drive cancer cell division by altering TCA flux and indirectly, cell cycle progression.DJGPhD
25/03/2023 Duração: 30minReferences Cell 2012 148DOI: (10.1016/j.cell.2012.01.031) Biotechnology Journal 2016. Volume11, Issue1 Special Issue: Biotech Methods and Advances: 71-79. Molecular Cancer. 2020. volume 19, Article number: 39. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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![ImmunoEpigenetics49.SiRNA knockdown of ME1 increases Haeme Oxygenase activity in both glucose supplemented and deprived cancer cells. The Pseudoparadox of epigenetic control over metabolism. DJGPhD]()
ImmunoEpigenetics49.SiRNA knockdown of ME1 increases Haeme Oxygenase activity in both glucose supplemented and deprived cancer cells. The Pseudoparadox of epigenetic control over metabolism. DJGPhD
23/03/2023 Duração: 29minReferences Dr Guerra's lectures and spontaneous expectorations. Molecular Cancer 2020. volume 19, Article number: 39 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
