Authentic Biochemistry

In this lecture I gather some of the notable molecular components of age-related decline and the contrarion opposition imposed by cell proliferation. Published 30 July 2020. DJGPhD.  --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Dan Guerra examines nutritional restriction and exercise in combination with anti-diabetic drugs to impact the aging process. Published 27 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra explains chain initiation, propagation and  termination during  lipid oxidation and the REDOX reactions of the electron transport chain  as a lead in to enzymatic oxidations and the plasticity of immune linked senescence. 26 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra lays out the reduction of molecular oxygen to water and the accumulation of intermediate free radical oxygen species that are reduced via enzymatic activity and anti=oxidants. Aging is related to the auto-oxidation of nucleic acids, protein and significantly, membrane unsaturated molecular species of lipids. 24 July 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra explains how  mutations in the glycolytic enzyme, pyruvate kinase,  may lead to histone phosphorylation and the florid production of pro-oncogenic events. 24 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr. Guerra delivers lecture 2 on human aging with a walk on the other side of cell fate:-pathobiochemical immortalization during oncogenesis. Published 21 July 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Today I start this robust examination of human aging from the fundamentals of life span and the molecular events that mediate the rate of senescence. This is Part One. Also please consider contributing to Authentic Biochemistry by becoming a patron on Patreon. I need your support!  https://podbay.fm/podcast/1454408625 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

The synthesis of protease-mediated hyper inflammation in pre-morbid respiratory distress pathobiochemical states linked to coronavirus transmission . How COPD and ARDS in association with cardiovascular disease, diabetes and lung dysfunction pre-dispose to viral infection and illness. Published 11 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Airway passage disease has been well characterized in  cystic fibrosis and this research which involves both clinical and animal model systems can inform general respiratory distress syndrome and viral pneumonia as that ascribed to the coronavirus 19. Published 10 July 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra presents his existential view on the purposive avoidance  in science to admit the significance of belief in the knowledge paradigm. 09 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra recaps protease mechanisms and zymogen activation ultimately linking serpin mediation of neutrophil elastase during coronavirus infection. Published 08 July 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra presents how a protease inhibitor protects a serine protease that is linked to ovarian cancer progression plus how protease inhibitor polymerization overloads the Endoplasmic Reticulum Associated Degradation pathway and Unfolded Protein Response to induce autophagy-linked Hepatocellular Carcinoma. Finally,  a mechanistic step-wise summary of the serine protease catalytic triad  is presented. Published 03 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Far from becoming monomeric and unimodal in effect, the anti-trypsin protease inhibitor functions to modulate the transcriptome and proteome of induced pro-inflammatory responses in both systemic and  tumor microenvironments.  Dr Dan Guerra 30 June 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra targets his lecture on protease inhibitors as positive acute phase proteins serving a modality of repression against proteolytic degradation processes as induced by the pro-inflammatory cytokine mediated hyper-immune response. Published 29 June 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this  session Dr Guerra discusses the physiological and pathophysiological roles of serine protease inhibitors (SERPINS). For example,  the physiological role of plasminogen activator inhibitor 1 (PAI-1) involves control over fibrinolysis  which is an essential  hemostatic mechanism for regulating the dissolution of fibrin clots associated with airway passage remodeling  systemic wound repair, and the inflammatory response as linked to cytokine mediated immune responses and circulating t-PA mediated cardiovascular function. Dr Guerra also mentioned that he has established a PATREON site:   https://www.patreon.com/user?u=37615512&fan_landing=true&fbclid=IwAR0L8ADIhtIgZM_WtkJejz_x-3hAdzr39mrvoZxdAu6glm9zkAG5L4NnhCo Lease strongly consider recombining with the Patreon link as a means to provide monetary donations to the Authentic Biochemistry Podcast and YouTube lecture series plus the VerEvMed Facebook postings that include Authentic Biochemistry "Minutes" and some

In this Lecture I define and then implement  a dialectical approach to biomedical scientific research methods that involves event ontologies relative to a non-paradoxical understanding of cancer pathobiochemistry. Published 19 June 2020 by Dr Daniel Guerra --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr. Dan Guerra apprehends several research publications going back to 2012  and proceeding through 2019 in a synthesis of oppostional logic and the published scientific evidence to explain the mediation of metabolic zonation, transcriptional control, and bioenergetcs using PEDF to mitigate cancer progression.   --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

A brief concluding lecture on   the linkage of obesity with Type 2 diabetes plus a clinical case study discussion and review question of a mis-diagnosis via anchoring.  --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra lays out the prodromal manifestations of metabolic syndrome and insulin resitance that can lead to Type 2 diabetes in the obese sedentary aging population. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra lays down the basics of bioenergetics and the roles of carbohydrate and lipid metabolism in the obese state leading to type 2 diabetes and the pathophysiological sequalae in chronic disease. 25 May 2020b. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message