Authentic Biochemistry

Professor Guerra arrives at the functionality of autophagy and bioenergetic coupling via chemokine and cytokine signalling through antigen presenting cell population mediated germ center secondary lymphoid organ resident B cell somatic hypermutation via T follicular-helper  cell activation thus evincing the autoimmune paradigmatic disease system lupus erythematosus. 28 January 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Authentic Biochemistry's Dr Dan Guerra gathers published  biomedical literature to offer mechanisms and means for sphingolipids  and amino acids to make a pathobiochemical donation to immunoepigenomic neurodegenerative disease. 21 January 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

19 January 2020. This is a podcast delivering Part 3 in my new arc describing the significance of biochemical and epigenetic reprogramming of T lymphocytes in human autoimmune disease. Parts 1&2 of this series are found as video lectures at https://www.youtube.com/playlist?list=UUcEoA2N9WSlNvDk1BtuznfQ. Dr Daniel J. Guerra of VerEvMed and Authentic Biochemistry.  --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra investigates T and B cell mediated autoimmune induction in this critical podcast lecture before the full analysis of these destructive human diseases are authentically examined in the peer-reviewed biomedical literature. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

As it turns out, autoimmune bacterial  epitope mimicry can play a crucial role in autoimmune primary biliary cholangitis and may correlate to major human disorders such as lupus . Prof. Guerra examines a series of papers from the primary literature to focus attenuation on T cell sub-population differentiating dynamics production.related to Plasma cell IgG  --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

T Lymphocyte communication with antigen presenting innate immune cells coupled with B cell activation may be regulated by a glycoprotein that links to discrete glycosylation patterns on membrane polypeptide domains --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

The epigenetic control over gene expression via transcriptional and post-transcriptional molecular interactions through time including interfering RNA and covalent modification of chromatin results in enivonmental, nutritional and age-related phenotypes . In this episode of Authentic Biochemistry, Dr. Guerra starts investigating  the molecular mechanisms employed. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Professor Guerra begins an arc of lectures on the molecular events that describe the covalent modification and temporal variation of gene expression collectively called epigenetics. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Prof Guerra gives a brief examination of Leptin -associated cancers. 15 October 2019 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra discusses the intricate roles of Leptin and its receptor in various human diseases. 10 October. 2019 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra of Authentic Biochemistry provides his  third discussion of adipokine-mediated control over obesity and associated disease from animal models to clinical disease. 02 October 2019. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Dan Guerra pursues how Leptin and POMC regulate neuroendocrine and neuro-appetitive behaviours that link obesity and associated metabolic and life-style disease with the dysregulation of energy homeostasis --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr. Guerra of Authentic Biochemistry and the VerEvMed YouTube channel provides critical in-depth neuro-anatomical and HPA axial complicity in Leptin Signaling from the Adipose to the stress- and basal regulation of human physiological responsiveness. 22 September 2019  --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this Authentic Biochemistry Podcast Episode Prof. Guerra describes the specific metabolism of very long chain polyunsaturated fatty acids from essential dietary precursors of both the Omega 6 and Omega 3 series and associates these pathways with a recent 2019 publication that provides evidence for Omega 3 fatty acid inhibition of adipose stem cell associated IL17a  proinflammatory  cytokine transcription thus inhibiting obese adipose inflammation. 08 September 2019.  --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Authentic Biochemistry's Dr Daniel Guerra implements his keen understanding of lipid metabolism to uncover the network of cellular, subcellular and pathway domains  regulating fatty acid oxygenation and both glycerol-and sphingosine- lipid signaling that function to mediate cell fate and the inflammatory response in relation to dietary omega three fatty acid.   04 Sept 2019. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr. Guerra of Authentic Biochemistry discusses a current published paper that shows how DHA and EPA derived from dietary alpha linolenic acid (18:3 cis  d 9,12,15) correlates with a decrease in the production of the pro-inflammatory cytokine, IL17-A in a model system composed of obese adipose stem cell populations. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

This is volume VI of the Tregs lecture narrative in which Dr. Guerra provides an introduction to a  Diaeventontological  process for navigating the labyrinth of T cell biochemistry. Published 17 August 2019.  Authentic Biochemistry Podcast.  --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Treg and Th cells are under transcriptional modulation via cytokine mediated control of a Nfil3 protein that serves to block FOXp3 expression.DR Guerra verifies the evidence in the data from a recent paper: Experimental & Molecular Medicine volume 51, Article number: 80 (2019) that demonstrated Inhibition of the TGF-β signaling pathway led to increased Nfil3 expression which blocked Foxp3 transcription via SMAD3. This is an important contribution to the T lymphocyte literature as it points to the proximal and distal modulation of T cell lineage differentiation, thus focusing attention to potential pharmacotherapeutic and immunoepigenetic mechanisms to control inflammation in diseases such as IBD while simultaneously suggesting strategies to reorganize the T cell profile to destroy tumors. Dr Daniel J Guerra, Authentic Biochemistry. 17 August 2019. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Prof. Guerra provides a narrative focusing on  evolutionary perspectives and  the resultant lymphocyte differentiating foundations for the adaptive immune response as a means to apprehend the event-ontological diverse transcriptional mediation ultimately landing on the Treg FOXp3 promoter . Part IV  --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this Authentic Biochemistry episode Dr Guerra unfolds the complex transcription factor and membrane & nuclear- receptor repertoire associated cytokine and chemokine axis activating and maintaining Treg cell differentiation to mediate the Th pro- inflammatory response --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message