Authentic Biochemistry

Besides 2-methoxy-17beta-estradiol, cell cycle arrest via chromatin deacetylation  can mitigate cell proliferation by decreasing global transcription while promoting the expression of tumor suppressor genes like p16INK4a while DNA Damage Repair (DDR) from pro-inflammatory cytokine production from senescent cells and Th1 lymphocytes can  inhibit commitment to mitosis and cytokinesis by generating the paracrine SASP paradigm. Refs. Am J Physiol Cell Physiol 2012;302:C1026-C1034 Steroids Volume 75, Issue 10, October 2010, Pages 625-631 Oncotarget. 2013 Oct; 4(10): 1552–1553 Cancer Metastasis Rev. 2020; 39(3): 681–709 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message