Authentic Biochemistry
Glycolysis is inhibited in T cells when Glucose 6 P non-competitively inhibits hexokinase after GLUT1 uptake of serum glucose:Setting the stage for lipogenesis.
- Autor: Vários
- Narrador: Vários
- Editora: Podcast
- Duração: 0:29:16
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Sinopse
Naïve T Cell metabolic regulationinvolves allosteric and kinetic mechanisms for maximum capacity to switch from glucose uptake to fatty acylCoA utilization for bioenergetic demand. Multiple mechanisms of this coordinated regulation involve the fatty acyl CoA concentration modulation by fine tuning cyctosolic fatty acid synthesis from glucose or lactate or amino acids vs. mitochondrial beta oxidation to drive the ATP concentration to levels necessary to prepare for cell proliferation and evenbtually cytokine synthesis and secretion. Published 06 January 2021. Dr Daniel J. Guerra, Authentic Biochemistry . --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
