Authentic Biochemistry

Dr. Guerra hybridizes multiple strands of published biochemical research to obtain an event ontology for potentiating factors leading to the aging human pathophysio9logical phenotype.  In this lecture  I include the following detail: 1. Nuclear factor interleukin 3 (NFIL3, also known as E4-binding protein 4, E4BP4) is a repressor of numerous genes. where an N-terminal domain directly binds to its response element, while the C-terminal region is responsible for homo- or heterodimerization to induce a temporally synchronized geometric configuration obtaining as a transcriptional repression domain 2. NFIL3 represses genes by recruiting histone deacetylase 2 and G9a histone methyltransferase in diverse physiological networks including the circadian clock,  acquired immune response, cell fate, and intermediary metabolism. Papers to read: Experimental & Molecular Medicine volume 51, Article number: 80 (2019) Journal of Molecular Endocrinology (2019) 63, R93–R102 SUPPORT AUTHENTIC BIOCHEMISTRY! Su