The Ezra Klein Show

On November 3, as the country fixated on the incoming presidential election results, voters in Oregon approved a seemingly innocuous ballot measure with revolutionary potential. Proposition 109, which passed with 56 percent of the vote (the same margin by which Joe Biden defeated Donald Trump in the state), legalizes the use of psilocybin, the main psychoactive compound found in magic mushrooms, in supervised therapeutic settings.    Multiple studies have found that use of psilocybin in a medical context has the power to cure depression, addiction, and anxiety at rates that no existing drug or therapy can boast (although these results still need to be replicated with larger sample sizes before drawing definitive conclusions). Scores of renowned scholars, artists, and entrepreneurs talk about their use of psychedelic drugs as one of the most important experiences of their entire lives. The details of how the Oregon initiative will be implemented still need to be worked out, but the prospect of making these dru