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Acid-Base or pH balance of your fluids is still the bottom line in all the following determinations. It is not known why yet, in physiological terms, but some people just don't do well on alkalinizing diets. Metabolic typing provides a good answer to this question and many others. http://www.life-enthusiast.com/index/Education/Pleomorphism/Metabolic_Typing The term biochemical individuality was coined by the biochemist Dr. Roger Williams. George Watson's book Nutrition and Your Mind: The Psychochemical Response, developed a protocol for assessing the health of individuals suffering from 'mental imbalances', based on the acidity or alkalinity of their venous blood. William L. Wolcott in 1983 showed that either the Oxidative or Autonomic control system determined a person's response to acid or alkaline foods. Francis M. Pottenger, M.D. in the 1930s and 1940s developed the relationship of nutrition to the sympathetic and parasympathetic divisions of the autonomic nervous system which are delineated in his book,