Meet The Microbiologist - The Scientists Behind The Microbiology

093: Biofilms and metagenomic diagnostics in clinical infections with Robin Patel

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Robin Patel discusses her work on prosthetic joint infections and how metagenomics is changing infectious disease diagnostic procedures. Take the listener survey: asm.org/mtmpoll Julie’s Biggest Takeaways: The term antimicrobial resistance can mean many things. Although acquisition of genetic elements can lead to drug resistance, so can different growth lifestyles of bacteria; the same bacteria growing in liquid culture may be more susceptible to a drug than those bacteria growing on a biofilm. Lifestyle and genetics can intertwine, however, when bacteria growing as a biofilm exchange resistance genes through horizontal gene transfer. How do bacteria reach an implanted surface, such as on a prosthetic joint, to cause infection? It may rarely occur during surgery, if even a single bacterium reaches the joint surface despite the sterile conditions; alternatively, it could occur through hematogenous spread (through the blood) after the surgery is over. Most infections are believed to be seeded at the time of imp