Meet The Microbiologist - The Scientists Behind The Microbiology

David Knipe is the Higgins Professor of Microbiology and Molecular Genetics at Harvard Medical school. A virologist, Dr. Knipe focuses his research efforts on the herpes simplex virus 2 (HSV-2) – the virus we have to thank for genital herpes. An astonishing 20% of Americans have been infected with HSV-2, and whether they’ve had a recognizable outbreak of sores or not, they can still carry the virus. Once you contract the HSV-2 it lays low in your nerve cells, waiting for the right moment to create watery blisters that eventually burst and release more virus particles. Dr. Knipe is interested in how the cells lead these two, very different lives: quiet and quiescent inside the nerve cell and loud and lytic in the epithelium on the surface of the body. Genital herpes is no picnic, but the effects of HSV-2 infection are worst in people with depressed immune systems and in newborns; babies who pick up the virus during birth may suffer from neurological damage, brain damage, or even death. There is no