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Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? No, We Should Never Again Compromise Safety! Diabetes Care. 2016 Jul;39(7):1281-6; Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What's the Fuss? Diabetes Care. 2016 Jul;39(7):1287-91 Food and Drug Administration. Metformin-containing Drugs: Drug Safety Communication – Revised Warnings for Certain Patients With Reduced Kidney Function.