Authentic Biochemistry

Journal of Neurochemistry, Volume: 146, Issue: 4, Pages: 416-428, First published: 20 May 2018, DOI: (10.1111/jnc.14464) Life Sci . 2019 Sep 1;232:116612 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

This is one of my classical biochemistry introductory lectures on amino acid utilization. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Trends in Immunology Volume 36, Issue 4, 2015, 217–228  Carcinogenesis 2015;36:1180-1192 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Clinical and Molecular Allergy volume 15, Article number: 21 (2017) Front. Immunol., 25 September 2019 | https://doi.org/10.3389/fimmu.2019.02247 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Oncotarget. 2013 Oct; 4(10): 1552–1553 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this episode Dr. Guerra provides the overview of Pharmacodynamics . --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

A.D.M.E. Anesthesiology Clinics, 2019-09-01, Volume 37, Issue 3, Pages 475-492. Please subscribe and donate! Dr. Guerra needs your support! --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Risk factors for aging morbidity are linked to large variations in protein synthesis and lack of adipose derived TAG utilization. The immune  response becomes compromised during aging leading to states of hyperinflammation followed by hypo-immune sequalae opening up the potential for opportunistic respiratory infections and alterations in pulmonary endothelial membrane lipid fluidity restricting oxygen intake. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Seminars in Cell & Developmental Biology Volume 40, April 2015, Pages 115-126 Pharmaceutical Research March 2018, 35:49 Journal of Molecular Endocrinology 2017. 58, 1; 10.1530/JME-16-0182 J. Lipid Res. 2018 59:(3) 488-506. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Feng, T., Yang, X., Hao, S. et al. Immunol Res. 05 April 2020 Molecular Neurodegeneration volume 7, Article number: 45 (2012) J Biol Chem. 2019 Jun 7;294(23):9213-9224 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Annu. Rev. Physiol. 2013. 75:685–705 Nutrients. 2020 Mar; 12(3): 622 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

FASEB J. 2013 Jun; 27(6): 2458–2467. Scientific Reports volume 7, Article number: 13763 (2017) --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Scientific Reports volume 9, Article number: 1220 (2019) Prog Neuropsychopharmacol Biol Psychiatry. 2005 Oct 12 Bulletin of Experimental Biology and Medicine.2003. 136.(3). 1573-8221  Pharmacological reports 2005, vol. 57, no6, pp. 811-817 Brain Res Bull, December 11, 2006; 71(1-3): 279-86. Journal of Endotoxin Research, Vol. 4, No. 5, 363-370 (1997) Scientific Reports volume 7, Article number: 13763 (2017) --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Brain Behav Immun. 2019 Oct;81:41-51 Neuroimmunomodulation 2002/2003;10:101-121 Front. Neurol., 23 January 2018 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

TLRs recognize molecular patterns associated with invasive pathogens. TIR domain-containing adaptors define the specificity of TLR signaling. TLR  interactions from CNS-resident microglia can obtain a pro-inflammatory environment that leads to neuronal degeneration as associated with classical aging related diseases like Parkinson's. J Neuroinflammation. 2014 Sep 20;11:166 Brain Behav Immun. 2019 Oct;81:41-51 J Mol Neurosci. 2021 Mar 9 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Pathogens, and abiotic ischaemic damage manifest a constellation of  molecular interactions triggering pattern recognition receptors such as TLR's, with canonical protein binding domains that signal through intracellular cascades such as activating  Ca2+ signaling; eo ipso obtaining potent hyperimmune inflammation,  providing  event ontological foundation and episodic contribution to the aging morbidity in human decline and mortality. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Oncotarget. 2016 Jan 26; 7(4): 4195–4209 Nature Reviews Immunology volume 6, pages644–658(2006) --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

The removal of damaged neurons and associated synaptic connections with the simultaneous repair of other neuronal circuits is a mechanism for the sculpting of the brain network and thus a means by which the highly innervated and connected prefrontal cortex can receive and respond to neurotransmission from the limbic system. Reference: Genes (Basel). 2019 Mar; 10(3): 249 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Authentic Biochemistry Podcast 27 April 2021 References Clin Diagn Lab Immunol. 2003 Jan;10(1):13-8 J Exp Med (2012) 209 (1): 187–199. Cell Reports 2020. V 30, (Issue 5) :1585-1597.e6 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

References Experimental & Molecular Medicine volume51, Article number: 80 (2019) Am J Nephrol.2017;46(5):371-379 EMBO Rep . 2003 Aug;4(8):774-80 J Biol Chem. 2020 Jul 3;295(27):9052-9060 Mol Immunol. 2017Aug;88:125-134 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message