Empowered Patient Podcast

Michelle Clavecilla-Chan, Director of Behavioral Health at MVP Health Care, and Amanda Conway, Chief Growth Officer at Aptihealth, have partnered to expand access to mental health services for MVP customers. Aptihealth provides virtual behavioral health services that connect patients to comprehensive mental health and substance abuse support. Through their digital platform and behavioral health provider network, MVP customers have options for integrated care that remove traditional access barriers and provide virtual visits to engage this high-need population. The partnership focuses on serving complex patient populations with conditions such as psychosis, bipolar disorder, ADHD, and personality disorders with personalized care plans. Michelle explains, "MVP provides coverage for all lines of business, including commercial Medicare, Medicaid, Child Health Plus, and Essential Plan enrollees. We provide all of the healthcare needs of our customers, and our mission is to improve our customers’ health and provi

Martin Pytela is a functional medicine expert, metabolic typing coach, and fellow podcaster. He discusses the principles of functional medicine and its focus on finding the root causes of health issues rather than just treating symptoms. Understanding metabolic behavior and how it can affect emotional well-being and overall health highlights the need to better understand the connection between diet and health conditions. Martin emphasizes the need to personalize approaches to health based on individual genetics and endocrine dominance. Martin elaborates, "Functional medicine is a moniker developed to distinguish it from allopathic medicine in the sense that functionals are looking for root causes of things. In the typical medical setting, you are just looking at a symptom, and you address the symptom with some chemicals and let the patient manage or cope with life as is. With functional medicine, you try to find the cause of it and restore health. So, rather than treating symptoms alone, you’re trying to hea

Patty Hayward, general manager for healthcare and life sciences at Talkdesk, talks about transforming the traditional call center into one that uses AI and large language models to make it easier for patients to get help and free up call center staff to focus on value-added tasks. The technology supports call center agents in their conversations with patients and helps avoid escalations. Outbound messaging prompts patients to take action, reinforcing conversations with call centers to improve patient outcomes.   Patty explains, "Because AI has been around for a long time, we’ve had AI infused in our platform for many years. But these large language models that have come speeding into the market have enhanced how we use AI in such a great way and allowed us to more easily support patients and agents in their journeys. We in healthcare do not make these journeys easy. They’re very complex. There are a lot of things going on, and quite frankly, deployment and training of these models can be really difficult. So

AJ Tesler, an award-winning producer and director who, along with his wife Jenny, is launching Magnolia’s Guide to Adventuring, a new documentary video series created with support from Acadia Pharmaceuticals, inspired by their daughter Magnolia’s experience with the rare genetic neurodevelopmental disease Rett syndrome. We’re also joined by Dr. Cary Fu, a pediatric neurologist at Vanderbilt University Medical Center, who emphasizes the need for early diagnosis. The video series highlights the adventures children with Rett syndrome can engage in.  While Cary emphasizes the importance of safety and consulting with specialists before pursuing an adventure, AJ and Cary encourage people to recognize the capabilities of children with Rett and focus on what they can do.   AJ explains, "We made a documentary about that experience and those initial steps that we took called Magnolia’s Hope, which is available on iTunes and Amazon streaming, as well as a bunch of other places. And in that documentary, my wife so sagely

David Mazzo, President and CEO of Lisata Therapeutics, has a lead program focused on metastatic pancreatic ductal adenocarcinoma. The Lisata CendR Platform and drug certepetide efficiently augment the effects of chemotherapy and immunotherapies in the tumor microenvironment. Based on early findings, the future of cancer treatment may involve combining existing therapies with certepetide to personalize treatment for most solid tumors. David explains, "At Lisata, we're developing therapies to combat a challenging problem in the medical field today, which is the effective treatment of solid tumors. Solid tumors are very difficult to treat for two very simple reasons. On the one hand, these tumors generate a layer of cells around them that acts as a physical barrier. It's called the tumor stroma, and it prevents the penetration of many anti-cancer medicines into the tumor, which is why you often don't get the kind of results that one would expect." "The other obstacle these tumors present is that they generate or

John Incledon, President and CEO of Hisamitsu America, the makers of Salonpas, has seen enormous growth in the acceptance of over-the-counter topical pain management options since introducing the Salonpas analgesic patch in the US market 37 years ago. This growth is partly due to television ads featuring doctors touting the benefits of Salonpas for mild to moderate nerve-related and muscle-related pain and the sampling program that aims to get doctors and patients to try out the products.   John explains, "Topical medications have only been around since the 1960s, with the introduction of the first OTC monograph by the FDA. Salonpas itself was formally introduced to the United States in 1987, so we’ve been around some 37 years or so as a brand in this country. And so, it’s been a challenge. I’ll give you a couple of fun facts: 85% of US households have a pill form of an OTC pain reliever in their house, and 30% have a topical analgesic of any sort, a cream, a roll-on, or a patch. So, there’s a great disparity

Dr. Doug Newton is the Chief Medical Officer at Rula Health, a tech-enabled provider group that offers therapy, psychiatry, care coordination, and other supportive behavioral health services with a whole-person approach. Mental health disorders are diagnosed and managed using a combination of sound clinical judgment and measurement-informed care, which involves using patient-reported data and other objective measures. Normalizing mental health and using objective measures can help doctors bring up the topic with people of all ages to develop a personalized plan to maintain good physical and psychological health.  Doug explains, "We do know that the behavioral health crisis was exacerbated by COVID. Still, unfortunately, for most demographic groupings, it was already starting before the pandemic hit.  Using adolescents as an example, because I’m a child, adolescent, and adult psychiatrist by training, I saw this trend, so I looked at the data. We saw that was already a problem for kids, adolescents, and adul

Professor Sir Peter Donnelly, Founder and CEO of Genomics plc, aims to use cutting-edge polygenic risk scores to identify inherited DNA mutations and genetic predispositions that could lead to common diseases. In partnership with the MassMutual life insurance company, Genomics offers a voluntary test that provides personalized risk measures and advice about conversations with clinicians. If the policyholder stays healthy longer, the insurance company will get paid more premiums before paying out to survivors. Win-win all the way around. Peter explains, "Until a few years ago, if I had the entire DNA sequence from a 40-year-old who’s currently healthy, I’d have learned something interesting and medically actionable in maybe 1% or 2% of cases. That’s because genetics has played into medicine through diseases where there’s a single change in our DNA, called a mutation, which often stops a crucial gene from working. Think cystic fibrosis or Huntington’s disease. Those are conditions that are individually serious

Oren Nissim, CEO and Co-Founder of Brook Health focuses on loneliness and its impact on individuals with chronic conditions, especially when access to support is limited. Societal stigma and guilt associated with chronic conditions often contribute to loneliness, which can include depression, lack of agency, and a sense of being alone. Brook Health provides nonjudgemental support to patients with chronic diseases using a combination of human interaction with health coaches and technology to help patients manage their conditions.   Oren elaborates, "I think that people who live at home with a condition need great support, and the reality is that they don’t always have access to great support. Even if they do have great support, they still go home and have to live with it themselves - it drives people to feel lonely. I can tell you from my personal experience that I’ve been living with diabetes for a very long period of time, and the reality is that living with a chronic condition is a very lonely thing to do

Kent Wakeford, Co-CEO and Co-Founder of Form Bio,  a company that provides computational solutions to scientists who are focused on cell and gene therapy to accelerate drug discovery and development, reduce costs, and ultimately make treatments more affordable for patients. Form Bio's in silico platform utilizes computational biology tools, bioinformatics, machine learning, and AI to process large amounts of open source data to provide insights to scientists to help them solve critical challenges. They are committed to supporting the rare and ultra-rare disease community and offer their tools to patient advocacy groups for free. Kent explains, "There are a lot of bumps. The production, scaling up, and cost of gene therapies are major obstacles to their widespread success. As we’ve seen in small molecule, target identification is one of the key challenges, and there’s been a lot of breakthroughs in AI, and computational analysis that have helped scientists find those targets." "In cell and gene therapy, it’

Ram Krishnan, CEO of Valant, works with therapists, psychologists, psychiatrists, and nurse practitioners in the outpatient behavioral healthcare environment, which has significant unmet needs that can be addressed with technology. Scaling a mental health practice differs from other medical practices due to the frequency of visits and the need for individualized care with the most effective therapist. Virtual visits and telehealth are helping providers bridge the gap between physical and mental health, and generative AI is showing promise in diagnosing and maintaining behavioral health.  Ram explains, "This has been a market that has evolved over the last 25 years because so much has changed with our overall perception of the value and importance of mental health. This is a market that was primarily rarely covered by insurance, and employers rarely demanded coverage for their employees. Therefore, it was a cash-based business for most of its existence." "But over the last ten years, as the stigma for mental

Fadi Micaelian, CEO of Sparkdit, and Dr. Andrew Fang, Chief of Orthopedics at Kaiser South San Francisco, have joined together to help patients and doctors make better treatment decisions by considering trade-offs and patient preferences. The platform can help reduce bias and incorporate patient desires into care while considering comorbidities and other factors that may affect treatment decisions. Fadi and Andrew agree that collaboration between technologists and clinicians is essential for advancing the use of AI in healthcare to augment human intelligence and improve outcomes. Fadi explains, "At Sparkdit, our mission is to teach computers to think like humans. To do so, we've taught computers to think with trade-offs. So humans universally think the same way. It doesn't matter where they're coming from. We all think the same way. Whenever we have a decision, we have a set of criteria that we take into account. We think in a certain way of each criterion, and then we apply on top of that a set of trade-offs

Sufian Chowdhury, CEO of Kinetik, highlights how the non-emergency medical transportation industry, which has about 20,000 local transportation providers and over 400,000 drivers, plays a pivotal role in the healthcare continuum. Kinetik is bringing digital tools to this environment to provide scheduling and real-time information to an industry that currently relies on the phone. The goal is to make the system more efficient, reduce waiting times for patients and drivers, and ensure that drivers get paid promptly for these rides Medicaid covers. Sufian explains, "These are pre-planned rides. This industry is non-digital. You have to liken the state of this industry to what the taxi industry was in the '90s. It’s a lot of telephonic communication. Not a lot of these transport companies are using technology. Because of that, the scheduling becomes very cumbersome, and some members have to request these rides three or four days in advance, not by choice but just because of the broken structure of this industry.

Piotr Orzechowski, CEO of Infermedica, works with health insurance companies, technology partners, public payers, and ministries of health to provide digital care navigation tools that enhance the patient experience with a healthcare provider. The highlight is the development of digital front door technology to support patients in finding appropriate care. Using an AI-powered care interface, symptoms can be evaluated, questions answered, and guidance offered for care options, including self-care at home. When appropriate, AI-based decision support tools guide nurses through phone conversations to triage and determine immediate actions that should be taken. Piotr explains, "We have developed a clinically validated symptom-checking tool powered by AI. I will explain it in a second. But most importantly, it’s curated by a team of 50 physicians. So, every single day, our group of doctors performs different tasks related to clinical validation and content updates, and using this content, we create probabilistic mo

Dr. Oren Cohen, President of Clinical Pharmacology and Chief Medical Officer at Fortrea, a global CRO spun-off from Labcorp, discusses the contract research environment and how it continues to change to meet the need for increased productivity in the development and testing of new drugs, devices, and treatments. One key goal is to work in close partnership with clients to include the patient's voice in trial design to increase diversity, drive recruitment, and improve retention.   Oren explains, "I think with all the pressure the industry is under productivity pressure, that’s changed massively. It’s a very heavy responsibility because we are entrusted with developing very precious intellectual property that represents the next generation of therapeutics for patients affected by all the diseases out there, from rare diseases to cancer to neurodegenerative diseases like Alzheimer’s. It’s a very exciting time. I think the science is moving very quickly, and we have the good fortune to be working on some very p

Dr. Will Chou, President and CEO of Passage Bio, is developing gene therapies for neurodegenerative diseases, with their lead product being PBFTO2, an AAV gene therapy for a specific genetic variant of frontotemporal dementia. They are also exploring the potential of raising progranulin levels to help patients with other neurodegenerative diseases. Passage Bio's gene therapy, utilizing AAV as the vector, is delivered through an ICM injection into the cisterna magna, bypassing the blood-brain barrier. Will explains, "What we’re doing is a little unique. We are starting in the normal way gene therapies approach this, which is we have a patient population with a specific genetic deficiency. They have frontotemporal dementia caused by a mutation in the granulin gene, in the GRN gene, which means they are deficient in creating a protein called progranulin. Our gene therapy product replaces that progranulin, and by replacing what they don’t have enough of, we hope to stop the neurodegenerative decline from this dis

Ben Zimmer, CEO of Priovant Therapeutics, focuses on developing therapies for rare autoimmune diseases specifically dermatomyositis, which affects the skin, muscles, and organs, and non-infectious uveitis, a severe ocular inflammatory condition. While these conditions are symptomatically different, mechanistically, they have features in common related to the underlying pathology of the diseases. The drug in development is an oral once-daily therapy that addresses the inflammatory conditions and cytokines driving the pathology. Ben explains, "During COVID, there was a lot of talk about the cytokine storm and these are molecules involved in immune cell signaling. So, they’re basically ways that different types of immune cells signal to each other to do different things. There’s a large variety of different cytokines and some autoimmune diseases. There are only maybe one or two cytokines or a small number that are driving the pathology of the disease."   "Both dermatomyositis and non-infectious uveitis are high

David Nichols, CEO of Orthobond aims to address the unmet need of medical device infection and contamination due to bacteria preventing devices from bonding to the bone or tissue. Orthobond's solution is the Ostaguard technology, which uses a molecule with a positive charge to attract and rupture bacteria. The technology is effective against common strains of bacteria and is primarily needed in the operating room, where medical devices can be exposed to bacteria before being implanted. This mechanical approach to fighting bacteria does not require a drug that can potentially create a superbug.  David explains, "Our bodies have great immune systems, and normally, it takes tens of millions of bacteria to cause an infection. However, numerous studies show that in the presence of an implant, a hip or a knee, or a pacemaker, it could take as few as 200 bacteria to cause an infection. When an implant goes in the body, it seems to overwhelm the immune system and can’t eradicate that bacteria from your body. It takes

Anupam Girdhar, CEO of medical and life sciences at Ascential Technologies, provides contract manufacturing services primarily to Fortune 100 companies, focusing on solving the most complex drug development and manufacturing challenges. By aligning with customers early on to understand the scope and risks of a project, Ascential can save time and money when bringing drugs and medical devices to market. At the same time, Anupam reminds us that innovation and inefficiency are part of the process for those trying to explore the unknown. Anupam explains, "This is where I enjoy some of the interactions we have with our customers, because if you think about fundamentally what the industry is trying to do, it is about democratizing care to the patients. We are all in the business of serving them and improving patients’ lives. A lot of these challenges that we encounter are mostly in the areas of, how do we provide access to more and more patients, as well as, how do we lower the cost fundamentally for both the comp

Dr. Abu Abraham, Chief Medical Officer at Cloudbreak Pharma,  discusses the disease burden and gaps in care for patients with Pterygium, also known as Surfer's eye. Pterygium is an ocular surface disorder that creates a growth on the eye's surface that can cause vision problems. The condition is more prevalent in individuals over 40, but it can also affect younger populations exposed to risk factors from spending time outside in the sun and being exposed to UV light. Cloudbreak Pharma is developing CBT-001, an investigational therapy, a multi-kinase inhibitor administered as an eye drop that aims to stop the progression of Pterygium. Abu explains, "Pterygium is a relatively common condition. It’s an ocular surface disorder. It’s a growth. The word Pterygium derives from the Greek pteryx, which means wedge-shaped. This growth is also a wedge shape that grows from the mucous membrane that overlies the white portion of a person’s eye and grows in the direction of the cornea. The cornea itself is a curved structu