Mds Podcast

Dr. Rick Helmich tells us about the role of functional MRI in understanding the circuits of tremor. The conversation starts with a description of his most famous theory on the pathophysiology of Parkinsonism tremor ('dimmer-switch' hypothesis) and moves towards other forms of tremors, such as dystonic, Holmes and essential and even physiological tremor.

Dr. Anna Latorre is interviewed by Dr. Sara Schaefer about her study exploring the role of transcutaneous spinal cord simulation for suppression of postural tremor in essential tremor, including the potential pathophysiological mechanisms and implications for therapeutic use. Journal CME is available until October 21, 2025 Read the article.

In the introductory episode for the Tremor Special Series, Dr. Elan Louis tells us about the epidemiology of tremor as well as patients' and health care providers' awareness (or lack thereof). He guides us through his journey from when his mentor suggested that he'd look into familial essential tremor to the most important discoveries of the last two decades. Finally he gives us a glimpse of what's about to come and why tremor matters.

Prof. Alessio Di Fonzo shares the results of his award winning, multi-center work examining genetic data from people with early-onset PD in hopes of highlighting the difficulties in interpreting genetic variants emerging from NGS-multigene panels. Read the article.

Dr. Hannah E. Reese and Mr. W. Alan Brown discuss their pilot study of a mindfulness-based group virtual intervention for tic disorders, that was co-developed with patients. Read the article.

Prof. Jeffrey Kordower shares the data in support of #PD being a copathology disease and what strategies may be in the future for protein aggregate clearance in age-related neurodegenerative diseases.

Alpha-synuclein based biomarkers have dominated the Parksinon's disease field over the past few years. Dr. Andrew Siderowf shares his views on the future of these biomarkers and what else the field may have in store.

Dr. Günter Höglinger discusses new genetic findings and other exciting research surrounding PSP and other atypical parkinsonisms.

Dr. Aesef Shaikh shares the exciting developments in the world of tremor and how he believes the use of technology will help answer some of the field’s big questions, including the personalization of treatment.

Dr. Victor Fung sat down with Dr. Michele Matarazzo at the #mdscongress to reflect on the advice from his predecessors and how that is helping him achieve his goals as MDS President.

Dr. Kishore Kumar shares the new genes associated with Parkinson's disease, dystonia, and ataxia. He also shares how new technologies, like long read sequencing, can assist in finding epigenetic changes.

Prof. Michael Zech takes a dive into his talk on gene discovery in dystonia. He explains how new findings can provide insight into the pathophysiology of dystonia and improve patient care and treatment.

Prof. Brit Mollenhauer shares her excitement about basic science, including biomarker research, and how she believes MDS’s diversity can help foster more collaboration between clinicians and basic scientists.

Dr. Alexander Lehn breaks down functional movement disorders; what is happening in the brain, what are the potential risk factors and what future treatments and clinical trials we have to look forward to.

The last full day of #mdscongress 2024 was packed full of sessions and other activities. Prof. Huw Morris dives into the learnings from the day and recollects the excitement surrounding the much-loved Video Challenge.

Informative plenaries, exciting grand rounds and a historical faculty dinner filled the third day of the #mdscongress. Prof. Irena Rektorova shares her favorite moments and key takeaways.

The second day of #mdscongress was filled with various sessions and activities, including the presidential lectures & networking events. Dr. Michiko Bruno shares her appreciation for MDS camaraderie, and which sessions caught her eye.

The first day of the #mdscongress has come to a close. Listen as Dr. Davide Martino recalls the exciting topics discussed in the plenaries; including treatment for early PD, device aided therapies, dystonia and tremor.

Dr. Sara Schaefer interviews Dr. Jennifer Goldman about her systematic review and meta-analysis on subjective cognitive complaints in Parkinson's disease, including the prevalence, epidemiology, and correlation with objective cognitive findings and neuropsychiatric disease. The article was recently named the Movement Disorders journal Review Article of the Year.

Award Replay: Dr. Eduardo Fernandez interviews Professor Günther Deuschl and Dr. Robin Wolke on their article on the challenges levodopa poses when predicting the outcome of subthalamic deep brain stimulation — which was recently named the Movement Disorders Clinical Practice journal Research Article of the Year. Read the article